SrasV1, Main, Exploration, bibRecord, 001C46

Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents.

Identifieur interne : 001C46 ( Main/Exploration ); précédent : 001C45; suivant : 001C47

Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents.

Auteurs : Li-Jun Wang [République populaire de Chine] ; Chang-An Geng ; Yun-Bao Ma ; Xiao-Yan Huang ; Jie Luo ; Hao Chen ; Xue-Mei Zhang ; Ji-Jun Chen

Source :

Bioorganic & medicinal chemistry letters [ 1464-3405 ] ; 2012.

RBID : pubmed:22520261

Descripteurs français

KwdFr :
- ADN viral (), ADN viral (biosynthèse), Antiviraux (), Antiviraux (pharmacologie), Antiviraux (synthèse chimique), Relation structure-activité, Réplication de l'ADN (), Réplication virale (), Virus de l'hépatite B (), Virus de l'hépatite B (génétique), Virus de l'hépatite B (physiologie), Énoxolone (), Énoxolone (pharmacologie), Énoxolone (synthèse chimique).
MESH :
- biosynthèse : ADN viral.
- génétique : Virus de l'hépatite B.
- pharmacologie : Antiviraux, Énoxolone.
- physiologie : Virus de l'hépatite B.
- synthèse chimique : Antiviraux, Énoxolone.
- ADN viral, Antiviraux, Relation structure-activité, Réplication de l'ADN, Réplication virale, Virus de l'hépatite B, Énoxolone.

English descriptors

KwdEn :
- Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), DNA Replication (drug effects), DNA, Viral (biosynthesis), DNA, Viral (drug effects), Glycyrrhetinic Acid (chemical synthesis), Glycyrrhetinic Acid (chemistry), Glycyrrhetinic Acid (pharmacology), Hepatitis B virus (drug effects), Hepatitis B virus (genetics), Hepatitis B virus (physiology), Structure-Activity Relationship, Virus Replication (drug effects).
MESH :
- chemical , biosynthesis : DNA, Viral.
- chemical , chemical synthesis : Antiviral Agents, Glycyrrhetinic Acid.
- chemical , chemistry : Antiviral Agents, Glycyrrhetinic Acid.
- chemical , drug effects : DNA, Viral.
- chemical , pharmacology : Antiviral Agents, Glycyrrhetinic Acid.
- drug effects : DNA Replication, Hepatitis B virus, Virus Replication.
- genetics : Hepatitis B virus.
- physiology : Hepatitis B virus.
- Structure-Activity Relationship.

Abstract

Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds 29, 32, 35, 41 exhibited significantly inhibitory activities against HBV DNA replication with IC(50) values of 5.71, 5.36, 8.90 and 9.08 μM, respectively. The structure-activity relationships (SARs) of GA derivatives were discussed for exploring novel anti-HBV agents.

DOI: 10.1016/j.bmcl.2012.03.081
PubMed: 22520261

Affiliations:

République populaire de Chine

Le document en format XML

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<term>DNA, Viral (biosynthesis)</term>
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<term>Glycyrrhetinic Acid (chemistry)</term>
<term>Glycyrrhetinic Acid (pharmacology)</term>
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<front><div type="abstract" xml:lang="en">Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds 29, 32, 35, 41 exhibited significantly inhibitory activities against HBV DNA replication with IC(50) values of 5.71, 5.36, 8.90 and 9.08 μM, respectively. The structure-activity relationships (SARs) of GA derivatives were discussed for exploring novel anti-HBV agents.</div>
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Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents.

Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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Pour mettre un lien sur cette page dans le réseau Wicri

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